Cellular inhibitors of apoptosis proteins ciap1 and ciap2 are increased after labour in foetal membranes and myometrium and are essential for tnf-α-induced expression of pro-labour mediators

Abstract

Problem: Inflammation is commonly associated with preterm birth. In non-gestational tissues, the cellular inhibitor of apoptosis protein (cIAP) 1 and 2, independent of their role in apoptosis, have emerged as important regulators of inflammation. There is, however, no data on the effect of human labour on the expression of cIAPs in human gestational tissues, or on their role in modulating TNF-α induced inflammation. Method of study: Myometrium and fetal membranes and myometrium were obtained from term non-labouring and labouring fetal membranes and myometrium. Fetal membranes were also obtained from preterm non-labouring and labouring fetal membranes with and without histological chorioamnio..